Dermal exposure to toluene diisocyanate and respiratory cancer risk
نویسندگان
چکیده
منابع مشابه
Respiratory response to toluene diisocyanate depends on prior frequency and concentration of dermal sensitization in mice.
Occupational asthma is the principal cause of work-related respiratory disease in the industrial world. In the absence of satisfactory models for predicting the potential of low molecular weight chemicals to cause asthma, we verified that dermal sensitization prior to intranasal challenge influences the respiratory response using toluene diisocyanate (TDI), a known respiratory sensitizer. BALB/...
متن کاملReference exposure levels for toluene diisocyanate
The Office of Environmental Health Hazard Assessment (OEHHA) is required to develop guidelines for conducting health risk assessments under the Air Toxics Hot Spots Program (Health and Safety Code Section 44360 (b) (2)). OEHHA developed a Technical Support Document (TSD) in response to this statutory requirement that describes acute, 8 hour and chronic RELs and was adopted in December 2008. The...
متن کاملChronic pulmonary function loss from exposure to toluene diisocyanate 1
In 1972 a total of 112 workers exposed to toluene diisocyanate (TDI) were examined for acute pulmonary function changes during a work shift on the first day of the working week. A dose-response relationship was demonstrated for the acute effects of TDI in this population. The cohort was restudied in 1974 to determine whether there was excessive loss of pulmonary function, and if so, whether the...
متن کاملBiological monitoring of occupational exposure to toluene diisocyanate.
The study validated the use of urinary toluene diamine (TDA) in postshift samples as an indicator of preceding 8-h exposure to toluene diisocyanate (TDI). Nine workers exposed in TDI-based polyurethane foam production were studied. Their exposure levels varied in 8-h time-averaged samples from 9.5 to 94 micrograms/m3. The urinary TDA concentrations varied from 6.5 to 31.7 micrograms/g creatinin...
متن کاملChronic pulmonary function loss from exposure to toluene diisocyanate.
In 1972 a total of 112 workers exposed to toluene diisocyanate (TDI) were examined for acute pulmonary function changes during a work shift on the first day of the working week. A dose-response relationship was demonstrated for the acute effects of TDI in this population. The cohort was restudied in 1974 to determine whether there was excessive loss of pulmonary function, and if so, whether the...
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ژورنال
عنوان ژورنال: Environment International
سال: 2017
ISSN: 0160-4120
DOI: 10.1016/j.envint.2017.09.017